Alan Browne will not be available for next month's Euro 2020 qualifiers against Denmark and Gibraltar.
The Preston midfielder picked up a calf injury during a training camp in Portugal and has been released by Mick McCarthy.
"Alan has been very unlucky with injuries this season," McCarthy said.
An ankle injury kept him out of the two games in March and now this calf problem has ruled him out of the matches against Gibraltar and Denmark.
The 24-year-old had a superb season for his club, scoring 12 times in 38 Championship appearances
The Ireland manager will not be calling up a replacement for Browne.
That leaves his midfield options as follows:
Alan Judge (Ipswich Town), Alan Browne (Preston North End), Glenn Whelan (Aston Villa), Jeff Hendrick (Burnley), Conor Hourihane (Aston Villa), Luca Connell (Bolton Wanderers), Josh Cullen (Charlton Athletic*), Robbie Brady (Burnley), Callum O'Dowda (Bristol City), James McClean (Stoke City), Ronan Curtis (Portsmouth)
McCarthy yesterday called up two goalkeepers to his squad, Bohs' James Talbot and Bristol City's Max O'Leary, after Mark Travers was forced to withdraw ahead of the games.
Picture credit: Sportsfile