Ireland winger James McClean has suffered a wrist injury during training. The 29-year-old broke the news via Instagram.
The full extent of the injury is not yet known, although surgery was required.
The FAI say that McClean was assessed by their medical team and then taken to hospital for an x-ray. Surgery immediately followed.
It is an unfortunate development for the Stoke midfielder, who has started life well in the Championship this season despite the team's disappointing opening.
It will also be a major blow to Martin O'Neill's plans, with Ireland set to open their UEFA Nation's League campaign away to Wales on Thursday evening and then play a friendly against Poland on Tuesday. McClean will miss both games.
Squad Update | James McClean has been ruled out of our UEFA Nations League opener with a wrist injury sustained in training. The midfielder will undergo surgery today. We wish James a speedy recovery. #COYBIG pic.twitter.com/bh5nK1sPmO
— FAIreland ⚽️🇮🇪 (@FAIreland) September 4, 2018
Ireland are already without a number of key personnel, with injury ruling out the likes of Robbie Brady, Shane Long and James McCarthy.
Harry Arter also withdrew himself from the squad, with a rumoured bust-up with assistant manager Roy Keane apparently the reason while Declan Rice is still deliberating over his international future.
Shane Duffy and David Meyler, who have groin and knee injuries, respectively, trained on Tuesday after sitting out Monday's session.