Morgan Schneiderlin, Bastian Schweinsteiger, Matteo Darmian and Memphis Depay all made their Manchester United debuts in a 1-0 win against Mexican side Club America.
The game was played at Centurylink Field in Seattle, home of MLS side the Sounders and NFL team the Seahawks.
Man Utd's winner came from Morgan Schniederlin just five minutes into the game when the Frenchman directed a looping header over the goalkeeper after a delicate ball in from Juan Mata.
David de Gea did not play for Louis van Gaal's side due to what the manager described as a 'minor injury'.
Some more highlights from the game below.