For long parts of the game, it appeared as though Laois were set for an easy win. However, Wexford fought back to make it a tense conclusion.
The game was Laois' first appearance at Croke Park since the county won its only senior title with a 2001 victory over Mayo.
"I am an absolute emotional wreck. I'm speechless," said Laois fullback, and Player of the Match, Aisling Donoher.
"I can't put into words what today means. The support Laois ladies have brought, thank you so much.
"We have worked so hard. It's been 20 long years coming, but we did it."
Laois had led by nine points at the break. That was a cushion they needed in the second half. Laois' win was powered by an excellent defensive display along with 1-5 by star forward Mo Nerney.
"We've been in this position before," said Donoher.
"We played Wexford in the Leinster semi-final, and we were 11 points up, and they came back and beat us by two points.
"You saw there, there was 30 seconds left on the clock, and there was a goal in it. It really wasn't over until she blew the whistle. My heart!"
Lán Ama #LAOvWEX
“It's been 20 long years coming but we did it!” 🏆
Is é Aisling Donoher Laoch na hImeartha inniu!
Comhghairdeas le Aisling agus @LaoisLadies!
BEO/LIVE AR @TG4TV pic.twitter.com/WLagfgJARJ
— Spórt TG4 (@SportTG4) July 31, 2022